Wednesday, November 25, 2009

Black dots or clods peripheral

Peripheral black dots or clods (globules) represent nests of growing melanocytes, the blacker they are the closer they are to the epidermal surface, and the more likely they are to represent melanoma. 




Brown peripheral dots are seen in growing nevi and in Spitz nevi with the brown colour indicating the nests are at the level of the dermoepidermal junction. 



Brown dots inside the circles of lines reticular indicate the cell nests are in the dermal papillae, a feature of benign compound nevi. (Kittler) (NB the lines reticular represent melanocytes concentrated in the rete ridges, hence anything inside them must be in the dermal papillae.)


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